Program Schedule

Update as of 13 Jan 2017

Venue: IAS Lecture Theater, Lo Ka Chung Building, Lee Shau Kee Campus, HKUST

14 Jan | 15 Jan | 16 Jan | 17 Jan | 18 Jan

14 Jan (Sat)

Event
Optional Pre-meeting Excursions (By Invitation Only)

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15 Jan (Sun)

Time Event
12:00-14:00
(*13:00)
Registration
*Pick-up at Crowne Plaza Hong Kong Kowloon East by coach
13:45-14:00 Introduction
Session 1: DNA Damage and Responses
Session Chair: Vilhelm Bohr
                          (National Institute on Aging, U.S. National Institutes of Health)
14:00-15:00 "Mechanisms of ATM Activation and Effects on Protein Homeostasis"
Tanya Paull (The University of Texas at Austin)
15:00-15:30 "How Cells Deal with Stress" [Abstract]
Michael Cox (University of Wisconsin-Madison)
15:30-16:00 Group Photo and Coffee Break
16:00-16:30 "Single-strand Breakage and Neurological Disease" [Abstract]
Keith Caldecott (University of Sussex)
16:30-17:00 "A Novel Function of NBS1 in Neural Development" [Abstract]
Zhao-qi Wang (Fritz Lipmann Institute)
17:00-17:30 Discussion
17:40 Pick-up at IAS to dining venue by coach
18:00-20:00 Dinner at Sai Kung (By Invitation Only)
20:00 Return to Crowne Plaza Hong Kong Kowloon East from dining venue by coach

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16 Jan (Mon)

Time Event
08:30 Pick-up at Crowne Plaza Hong Kong Kowloon East by coach
Session 1: DNA Damage and Responses
Session Chair: Tone Tønjum (Oslo University Hospital)
09:00-10:00 "Non-canonical Aspects of ATM and p53 Signaling Pathways"
Michael Kastan (Duke University)
10:00-10:30 "Mitochondrial Function Regulates Nucleotide Metabolism and Affects Genomic Stability: Mechanisms and Biomarker for Cognitive Function" [Abstract]
Lene Juel Rasmussen (University of Copenhagen)
10:30-11:00 Coffee Break
11:00-11:30 "DNA Damage in Ageing and the Role of Non Coding RNAs"
Fabrizio d’Adda di Fagagna (IFOM, the FIRC Institute of Molecular Oncology Foundation and the Institute of Molecular Genetics [IGM] - Italy National Research Council [CNR])
11:30-12:00 "Epigenomics and Cellular Function"
Danny Leung (The Hong Kong University of Science and Technology)
12:00-12:30 Discussion
12:30-14:00 Lunch at G/F Chinese Restaurant (By Invitation Only)
Session 2: Genome Dynamics in Homeostasis
Session Chair: Lene Juel Rasmussen (University of Copenhagen)
14:00-14:30 "Polynucleotide Kinase-phosphatase and Neurogenesis"
Peter McKinnon (St. Jude Children's Research Hospital)
14:30-15:00 "Protein Interaction in DNA Damage Response"
Junjie Chen (The University of Texas MD Anderson Cancer Center)
15:00-15:30 "Dynamics Neuro-glio-cerebellar Networks"
Ari Barzilai (Tel Aviv University)
15:30-16:00 Coffee Break
Session 3: Stem Cells and Single Cells
Session Chair: Lene Juel Rasmussen (University of Copenhagen)
16:00-16:30 "Muscle Stem Cells"
Tom Cheung (The Hong Kong University of Science and Technology)
16:30-17:00 "Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line" [Abstract]
Ronald Hart (Rutgers, The State University of New Jersey)
17:00-17:30 Discussion
17:40 Pick-up at IAS to dining venue by coach
18:30-20:30 Dinner at Tsim Sha Tsui (By Invitation Only)
20:30 Return to Crowne Plaza Hong Kong Kowloon East from dining venue by coach

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17 Jan (Tue)

Time Event
08:30 Pick-up at Crowne Plaza Hong Kong Kowloon East by coach
Session 4: Nervous System I
Session Chair: Michael Huen (The University of Hong Kong)
09:00-10:00 "Recurrent DNA Break Cluster Genes in Neural Stem and Progenitor Cells" [Abstract]
Frederick Alt (Boston Children’s Hospital and Harvard Medical School) 
10:00-10:30 "The Response of Neural Stem Cells to Radiation Exposure"
Penny Jeggo (University of Sussex)
10:30-11:00 "Ploidy of the Neuronal Nucleus"
Jerold Chun (Sanford Burnham Prebys Medical Discovery Institute)
11:00-11:30 Coffee Break
11:30-12:00 "A Genome Wide Search for DNA Breaks in Neurons"
Andre Nussensweig (National Cancer Institute, U.S. National Institutes of Health)
12:00-12:30 Discussion
12:30-14:00 Lunch at Lounge, 5/F, IAS Building (By Invitation Only)
Session 5: Aging
Session Chair: Zhongjun Zhou (The University of Hong Kong)
14:00-15:00 "Genome Dynamics, Cellular Senescence and Age-related Neurodegeneration" [Abstract]
Judith Campisi (The Buck Institute for Research on Aging)
15:00-15:30 "DNA Damage: Impact on Aging and the Effect of Nutritional Interventions on Neurodegeneration" [Abstract]
Jan Hoeijmakers (Erasmus University Medical Center Rotterdam)
15:30-16:00 "Linking Genome Stability, Neurodegeneration and Aging: ATM and Colleagues"
Yosef Shiloh (Tel Aviv University)
16:00-16:30 Coffee Break
16:30-17:00 "When Transcription and Replication Collide: A BRD4-TopBP1 Interaction Controls Activation of the ATR-Chk1 Pathway During Transcription-Replication Collision Events in Oncogenic Cells" [Abstract]
Fred Lam (Massachusetts Institute of Technology)
17:00-17:30 "Nuclear to Mitochondrial DNA Damage Signaling in Neurodegeneration" [Abstract]
Vilhelm Bohr (National Institute on Aging, U.S. National Institutes of Health)
17:30-18:00 Discussion
18:10 Pick-up at IAS to dinning venue by coach
19:00-21:00 Dinner Banquet at Causeway Bay (By Invitation Only)
21:00 Return to Crowne Plaza Hong Kong Kowloon East from dining venue by coach

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18 Jan (Wed)

Time Event
08:30 Pick-up at Crowne Plaza Hong Kong Kowloon East by coach
Session 6: Neurodegenerative Disease
Session Chair: Yosef Shiloh (Tel Aviv University)
09:00-10:00 "Aberrant DNA Damage/Repair and Neuronal Dysfunction in Alzheimer’s Disease"
Lennart Mucke (Gladstone Institute of Neurological Disease & University of California at San Francisco)
10:00-10:30 "Neuroinflammation Contributes to the Neuronal Phenotype in Ataxia-telangiectasia: A Rat Model of Ataxia-telangiectasia" [Abstract]
Martin Lavin (The University of Queensland)
10:30-11:00 "The Brain-Gut Axis: Differential Expression of DNA Repair Pathways in Brain and Mucosal Gut Tissue" [Abstract]
Tone Tønjum (Oslo University Hospital)
11:00-11:30 Coffee Break
11:30-12:00 "DNA Damage in Neurodegenerative Diseases – Beyond Neurons"
Karl Herrup (The Hong Kong University of Science and Technology)
12:00-12:30 Wrap up and Final Discussion
12:30-14:00 Lunch at G/F Chinese Restaurant (By Invitation Only) and Departure
14:15 Return to Crowne Plaza Hong Kong Kowloon East by coach

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